生物统计学和生物信息学最新进展

图书标准信息

• 作者 范剑青、林希虹、刘军 编
• 出版社 高等教育出版社
• 出版时间 2009-01
• 版次 1
• ISBN 9787040247558
• 定价 49.00元
• 装帧 精装
• 开本 16开
• 纸张 胶版纸
• 页数 269页
• 字数 355千字
• 正文语种 英语
• 丛书 统计前沿

【内容简介】

presentsanoverviewofrecentdevelopmentsinbiostatisticsandbioinformatics.Writtenbyactiveresearchersintheseemergingareas,itisintendedtogivegraduatestudentsandnewresearchersanideaofwherethefrontiersofbiostatisticsandbioinformaticsareaswellasaforumtolearncommontechniquesinuse,sothattheycanadvancethefieldsviadevelopingnewtechniquesandnewresults.Extensivereferencesareprovidedsothatresearcherscanfollowthethreadstolearnmorecomprehensivelywhattheliteratureisandtoconducttheirownresearch.Inparticulars,thebookcoversthreeimportantandrapidlyadvancingtopicsinbiostatistics:analysisofsurvivalandlongitudinaldata,statisticalmethodsforepidemiology.

【目录】

Preface
PartⅠAnalysisofSurvivalandLongitudinalData
Chapter1Non-andSemi-ParametricModelinginSurvivalAnalysis
1Introduction
2Cox'stypeofmodels
3MultivariateCox'stypeofmodels
4ModelselectiononCox'smodels
5ValidatingCox'stypeofmodels
6Transformationmodels
7Concludingremarks
References
Chapter2Additive-AcceleratedRateModelforRecurrentEvent
1Introduction
2Inferenceprocedureandasymptoticproperties
3Assessingadditiveandacceleratedcovariates
4Simulationstudies
5Application
6Remarks
Acknowledgements
Appendix
References
Chapter3AnOverviewonQuadraticInferenceFunctionApproachesforLongitudinalData
1Introduction
2Thequadraticinferencefunctionapproach
3Penalizedquadraticinferencefunction
4SomeapplicationsofQIF
5Furtherresearchandconcludingremarks
Acknowledgements
References
Chapter4ModelingandAnalysisofSpatiallyCorrelatedData
1Introduction
2Basicconceptsofspatialprocess
3Spatialmodelsfornon-normal/discretedata
4Spatialmodelsforcensoredoutcomedata
5Concludingremarks
References

PartⅡStatisticalMethodsforEpidemiology
Chapter5StudyDesignsforBiomarker-BasedTreatmentSelection
1Introduction
2Definitionofstudydesigns
3Testofhypothesesandsamplesizecalculation
4Samplesizecalculation
5Numericalcomparisonsofefficiency
6Conclusions
Acknowledgements
Appendix
References
Chapter6StatisticalMethodsforAnalyzingTwo-PhaseStudies
1Introduction
2Two-phasecase-controlorcross-sectionalstudies
3Two-phasedesignsincohortstudies
4Conclusions
References

PartⅢBioinformatics
Chapter7ProteinInteractionPredictionsfromDiverseSources
1Introduction
2Datasourcesusefulforproteininteractionpredictions
3Domain-basedmethods
4Classificationmethods
5Complexdetectionmethods
6Conclusions
Acknowledgements
References
Chapter8RegulatoryMotifDiscovery"FromDecodingtoMeta-Analysis
1Introduction
2ABayesianapproachtomotifdiscovery
3Discoveryofregulatorymodules
4Motifdiscoveryinmultiplespecies
5MotiflearningonChiP-chipdata
6Usingnucleosomepositioninginformationinmotifdiscovery
7Conclusion
References
Chapter9AnalysisofCancerGenomeAlterationsUsingSingkNucleotidePolymorphism(SNP)Microarrays
1Background
2LossofheterozygosityanalysisusingSNParrays
3CopynumberanalysisusingSNParrays
4High-levelanalysisusingLOHandcopynumberdata
5SoftwareforcanceralterationanalysisusingSNParrays
6Prospects
Acknowledgements
References
Chapter10AnalysisofChiP-chipDataonGenomeTilingMicroarrays
1Backgroundmolecularbiology
2AChiP-chipexperiment
3Datadescriptionandanalysis
4Follow-upanalysis
5Conclusion
References
SubjectIndex
AuthorIndex