药用高分子材料
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天津西青
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出版社化学工业出版社
ISBN9787122218131
出版时间2015-01
装帧平装
开本16开
定价49元
货号1201008601
上书时间2024-11-27
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目录
Chapter 1. Introduction to Pharmaceutical Excipients
药用辅料概述1
1.1 Definition of pharmaceutical excipients1
1.2 What are excipients doing in medicines?2
1.3 Quality and safty of excipients3
1.4 Relationship between polymers and pharmaceutical excipients5
1.5 Specific notes for polymers used in drug delivery system6
本章中文导读7
References9
Chapter 2. Introduction to Polymers
高分子材料概述10
2.1 What are polymers?10
2.2 Polymer structure and morphology11
2.2.1 Molecular weight11
2.2.2 Configuration and conformation12
2.2.3 Chain structure14
2.2.4 Crystalline15
2.3 Synthesis17
2.3.1 Addition polymerization17
2.3.2 Condensation polymerization19
2.3.3 Cross-linking reaction19
2.4 Characteristic properties of polymers20
2.4.1 Thermal properties20
2.4.2 Mechanical properties22
2.4.3 Viscoelastic properties23
2.5 Characterization techniques23
2.5.1 Determination of molecular weight23
2.5.2 Determination of structure24
2.5.3 Differential scanning calorimetry25
2.6 Fabrication and processing26
2.6.1 Injection molding27
2.6.2 Extrusion27
2.6.3 Spinning27
本章中文导读28
References32
Chapter 3. Natural Polymers as Pharmaceutical Excipients
天然来源的药用高分子辅料33
3.1 Starch and its derivates33
3.1.1 Starch33
3.1.2 Pregelatinized starch36
3.1.3 Dextrin37
3.1.4 Cyclodextrin39
3.1.5 Sodium carboxymethyl starch42
本节中文导读44
3.2 Cellulose and its derivates46
3.2.1 Microcrystalline cellulose46
3.2.2 Powdered cellulose47
3.2.3 Methylcellulose48
3.2.4 Ethylcellulose50
3.2.5 Hydroxyethyl cellulose52
3.2.6 Hydroxypropyl cellulose54
3.2.7 Hydroxypropyl methylcellulose56
3.2.8 Carboxymethylcellulose sodium59
3.2.9 Carboxymethylcellulose calcium60
3.2.10 Cellulose acetate phthalate61
本节中文导读63
3.3 Other natural polymers in pharmaceutics66
3.3.1 Chitin/chitosan66
3.3.2 Alginate and sodium/calcium alginate68
3.3.3 Acacia71
3.3.4 Xanthan gum72
3.3.5 Gelatin74
3.3.6 Albumin76
本节中文导读78
References80
Chapter 4. Synthetic Polymers as Pharmaceutical Excipients
合成的药用高分子敷料81
4.1 Polymers based on polyvinyl81
4.1.1 Polyvinyl alcohol81
4.1.2 Polymethacrylates83
4.1.3 Polyvinylpyrrolidone (Povidone)87
4.1.4 Crospovidone89
4.1.5 Carbomer90
本节中文导读93
4.2 Polymers based on polyether95
4.2.1 Polyethylene glycol95
4.2.2 Poloxamer99
4.2.3 Polysorbates102
本节中文导读105
References106
Chapter 5. Novel Synthetic Biodegradable Polymers as Drug
Delivery Carrier
新型可生物降解的合成药用高分子材料107
5.1 Introduction107
5.2 Polymers based on polyester108
5.2.1 Poly(lactic acid) and poly(lactic-co-glycolic acid) copolymers108
5.2.2 Polycaprolactone111
5.2.3 Poly(β-hydroxybutyrate)112
5.3 Other biodegradable polymers113
5.3.1 Poly(orthoesters)113
5.3.2 Poly(phosphate esters)115
5.3.3 Polyanhydrides116
5.3.4 Poly(amino acids)117
5.3.5 Polyphosphazenes119
本章中文导读121
References124
Chapter 6. Advanced Applications of Functional Polymer in Drug Delivery
功能高分子材料在药物输送中的应用进展125
6.1 Hydrogels for pharmaceutical application125
6.1.1 Introduction125
6.1.2 Preparation of hydrogels126
6.1.3 Properties of hydrogels127
6.1.4 Pharmaceutical applications of hydrogels129
本节中文导读133
6.2 Polymer-based nanomedicine and self-assemblying polymers134
6.2.1 Introduction to nanomedicine134
6.2.2 Micellation of self-assemblying polymers134
6.2.3 Biological significance of polymeric micelles136
6.2.4 Drug release from polymeric micelles137
6.2.5 Examples of polymeric micelles for drug delivery138
本节中文导读141
6.3 Polymer-drug conjugates142
6.3.1 Introduction142
6.3.2 Design and development of polymer-drug conjugates144
6.3.3 Examples for polymer-drug conjugates146
本节中文导读152
6.4 Polymers for gene delivery153
6.4.1 Introduction to gene delivery153
6.4.2 Polymeric vectors154
本节中文导读161
References162
内容摘要
药用高分子材料是药物制剂不可缺少的物质基础，系统学习了解药用高分子材料相关知识，是现代药学科技工作者，尤其是药剂学专业学生的迫切需要。本书是编者总结十余年的教学经验，参考大量英文原版文献和书籍并选取适合教学大纲要求的内容编写而成，主要内容以英文编写，并对关键知识点配以中文导读，便于学生阅读和理解。全书共分6章，内容包括：药用辅料概述；高分子材料概述；常用天然高分子辅料和合成高分子辅料的结构、性质及其在药剂学中的应用；新型生物可降解的合成药用高分子材料；最后介绍了新型药物输送体系中的药用水凝胶材料、纳米制剂与自组装高分子、高分子药物轭合物和高分子基因载体。本书可作为药学专业本科生教材和药剂学专业研究生参考教材，也可供药学、医学和高分子材料学等方面的科技工作者参考。
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