蛇葡萄素和运动模拟剂在慢性疾病中的生物功能及机制(英文版)
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天津西青
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作者寇现娟
出版社华中科技大学出版社
ISBN9787568043007
出版时间2018-06
装帧平装
开本16开
定价42元
货号1201999480
上书时间2024-10-12
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作者简介
寇现娟，女，副教授。健康科学学院运动医学教研室教师。郑州大学医学院生物化学与分子生物学专业硕士，华中科技大学同济医学院生物化学与分子生物学专业博士。
目录
Chapter 1 Pharmacological potential of ampelopsin in Rattan tea Chapter 2 Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-KB signaling pathways Chapter 3 Natural products for cancer prevention associated with Nrf2-ARE pathway Chapter 4 Anti-tumor effect 4.1 Potential molecular targets of ampelopsin in prevention and treatment of cancers 4.2 Nutraceutical or pharmacological potential of Moringa oleifera Lam 4.3 Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways:involvement of p38 and ERK Chapter 5 Neuroprotective effect 5.1 Ampelopsin inhibits H2O2-induced apoptosis by ERK and Akt signaling pathways and up-regulation of heme oxygenase 5.2 Ampelopsin attenuates 6-OHDA-induced neurotoxieity by regulating GSK-3β/NRF2/ARE signaling Chapter 6 Autophagy and brain aging 6.1 Autophagy as the modulator of neuronal homeostasis and neurodegenerative disorders 6.2 Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer s disease 6.3 Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signaling pathway 6.4 Swimming attenuates D-galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics 6.5 Voluntary wheel running exercise suppresses brain aging of rats through activating miR-130a-mediated autophagy Chapter 7 Sarcopenia 7.1 Research progress of sarcopenia 7.2 MicroRNA-regulated proinflammatory cytokines in sarcopenia 7.3 Ampelopsin attenuates D-gal-induced oxidative stress-related skeletal muscle atrophy through activating AMPK/SIRT1/PGC-lα signaling cascade 7.4 Role and regulation of autophagy in mass maintenance of skeletal muscle Acknowledgement References
内容摘要
蛇葡萄素（Ampelopsin）又名双氢杨梅素（dihydromyricetin，DMY）是藤茶中一种重要的黄酮类物质。研究表明，Ampelopsin具有广泛的生物学功能：抗炎、抗氧化、抗肿瘤、保肝、改善运动疲劳等。本书首从Ampelopsin的结构入手，然后分章节来探讨Ampelopsin的抗炎、抗氧化、抗肿瘤、保肝、神经保护、改善运动疲劳及衰老性肌萎缩的作用；阐明Ampelopsin发挥上述作用的信号分子或者靶标；Ampelopsin发展成为功能性食品的前景。
主编推荐
1．本书为英文专著，为开发中国的传统药物带来更大的发展空间。2.本书可以成为中药学或生物学相关专业教材用书。3.本书研究水平水平较高，已发表高水平的SCI论文6篇，并深受同行专家的高度赞扬。4. 本书出版将会进一步拓展Ampelopsin在临床的应用范围，为炎性疾病、神经退行性疾病及肿瘤疾病的联合治疗提供理论依据。
精彩内容
Ampelopsis grossedentata is widely distributed in the South of China.Its tender stems and leaves are exploited in China to prepare a health beverage named as Rattan tea.Ampelopsin is one of the most important flavonoids found in Rattan tea.As a dihydromyricetin (DHM)，ampelopsin was first isolated from Ampelopsis meliaefolia by Kotake and Kubota in 1940，and was reported as a major bioactive component in Ampelopsis grossedentata later.Nowadays，ampelopsin，as a major bioactive component in Rattan tea，has a broad range of biological functions.During the past decade，the bioactivity of ampelopsin in Rattan tea has gained extensive attention and increasing scientific investigations related to its pharmacological functions and underlying mechanisms have been reported.Herein，the current research progress in the pharmacological functions and corresponding action mechanisms as well as potential benefits in chronic diseases have been summarized.This study will start a series of studies of ampelopsin from the following aspects：antiinflammatory，antioxidative，antitumor and neuroprotective effects，and alleviate brain aging and sarcopenia.We mainly focus the effect and molecular mechanism of ampelopsin on inflammation，tumor and neuroprotective effects in different cells and animal models.
Many intervention strategies have been investigated in order to understand their ability for slowing down the aging process of brain and skeletal muscle，and exercise training has been confirmed to inhibit oxidative stress and apoptotic signaling，thus effectively executing neuroprotection and sarcopenia.Aerobic exercise，such as running，has been proven to be a very effective way to improve adult hippocampal neurogenesis and learning.Some reports have also shown that treadmill and voluntary wheel running can improve behavioral performance and accelerate mitochondrial fitness of brain by reducing oxidative damage，rescuing abnormal mitochondrial dynamics，and inhibiting excessive apoptotic signaling.
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