医学分子生物学（英文改编版）
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作者药立波,卜友泉,[美]罗伯特·韦弗
出版社中国科技出版传媒股份有限公司
ISBN9787030629548
出版时间2019-11
装帧平装
开本其他
定价298元
货号9717121
上书时间2024-12-30
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作者简介
药立波教授 （1955年1月1日- ）山西左权人。1988获第四军医大学生物化学专业博士学位。先后留学日本、美国，1996年回国。现任第四军医大学生物化学与分子生物学教研室主任、教授，博士生导师，国家重点学科及军队重点实验室主任。担任教育部科技委生物学部委员、国务院学科评议组成员、全军第七届科委会委员、全军生物化学与分子生物学专业委员会副主任委员、陕西省生物化学与分子生物学学会理事长、中国生物化学与分子生物学学会理事、全国医药院校教材建设委员会理事、中华医学科技奖和中华医学青年奖评审委员会委员等学术职务。
目录
CONTENTS
CHAPTER 1 INTRODUCTION 1
SECTION 1 A BRIEF HISTORY 1
SECTION 2 MOLECULAR BIOLOGY PROMOTE MEDICINE TO THE MOLECULAR LEVEL 11
CHAPTER 2 THE MOLECULAR NATURE OF GENES 16
SECTION 1 THE NATURE OF GENETIC MATERIAL 16
SECTION 2 STRUCTURE OF NUCLEIC ACIDS 21
SECTION 3 NUCLEOSOME AND CHROMATIN ASSEMBLY 27
SECTION 4 PHYSICAL CHEMISTRY OF NUCLEIC ACIDS 35
CHAPTER 3 NATURE AND FUNCTION OF GENES 42
SECTION 1 THE NATURE OF GENES 42
SECTION 2 PROTEIN STRUCTURE AND FUNCTION 43
SECTION 3 OVERVIEW OF GENE EXPRESSION 49
SECTION 4 REPLICATION 57
SECTION 5 MUTATIONS 58
CHAPTER 4 DNA REPLICATION OF PROKARYOTES 62
SECTION 1 GENERAL FEATURES OF PROKARYOTIC DNA REPLICATION 62
SECTION 2 ENZYMOLOGY OF PROKARYOTIC DNA REPLICATION 69
SECTION 3 DETAILED PROCEDURES OF PROKARYOTIC DNA REPLICATION 79
CHAPTER 5 DNA REPLICATION OF EUKARYOTES 92
SECTION 1 FEATURES OF EUKARYOTIC DNA REPLICATION SYSTEM 92
SECTION 2 DETAILED PROCEDURES OF EUKARYOTIC DNA REPLICATION 103
SECTION 3 TELOMERES AND CANCER 109
CHAPTER 6 DNA DAMAGE AND REPAIR 111
SECTION 1 POLYMORPHISM AND MUTATION OF GENETIC MATERIALS 111
SECTION 2 DNA DAMAGE 112
SECTION 3 DNA REPAIR 115
SECTION 4 OUTCOME OF FAILURE TO REPAIR THE DAMAGED DNA 125
CHAPTER 7 TRANSCRIPTION IN PROKARYOTES 130
SECTION 1 COMPONENTS OF THE PROKARYOTIC TRANSCRIPTION SYSTEM 130
SECTION 2 PROCESS OF THE PROKARYOTIC TRANSCRIPTION 133
CHAPTER 8 REGULATION OF PROKARYOTIC TRANSCRIPTION 142
SECTION 1 GENERAL CONSIDERATIONS ON PROTEIN–DNA INTERACTION 142
SECTION 2 OPERONS: FINE CONTROL OF BACTERIAL TRANSCRIPTION 143
CHAPTER 9 TRANSCRIPTION IN EUKARYOTES 164
SECTION 1 THE EUKARYOTIC TRANSCRIPTION SYSTEM 164
SECTION 2 PROCESS OF THE EUKARYOTIC TRANSCRIPTION 179
CHAPTER 10 REGULATION OF TRANSCRIPTION IN EUKARYOTES 193
SECTION 1 TRANSCRIPTIONAL ACTIVATORS: DEFINITION， CATEGORIES AND MECHANISMS 193
SECTION 2 TRANSCRIPTIONAL REPRESSORS 212
SECTION 3 CHROMATIN REMODELING AND TRANSCRIPTION 213
SECTION 4 REGULATION OF TRANSCRIPTION FACTORS 223
SECTION 5 TRANSCRIPTIONAL COACTIVATORS AND COREPRESSORS 224
SECTION 6 SIGNALING PATHWAYS THAT REGULATE TRANSCRIPTION 230
CHAPTER 11 POST-TRANSCRIPTIONAL EVENTS AND REGULATION 238
SECTION 1 RNA SPLICING 238
SECTION 2 CAPPING AND POLYADENYLATION 250
SECTION 3 OTHER POST-TRANSCRIPTIONAL MECHANISMS OF MRNA REGULATION 260
SECTION 4 PROCESSING EVENTS OF OTHER RNAS 269
CHAPTER 12 TRANSLATION 276
SECTION 1 THE CELLULAR APARATUS FOR TRANSLATION 276
SECTION 2 INITIATION OF TRANSLATION 291
SECTION 3 ELONGATION AND TERMINATION OF TRANSLATION 306
CHAPTER 13 POST-TRANSLATIONAL EVENTS 323
SECTION 1 POST-TRANSLATIONAL PROCESSING AND PROTEIN TRAFFICKING 323
SECTION 2 SITE-SPECIFIC MODIFICATION OF PROTEINS 329
SECTION 3 PROTEIN DEGRADATION 336
CHAPTER 14 DNA RECOMBINATION， TRANSPOSITION & EDITING 341
SECTION 1 THE HOMOLOGOUS RECOMBINATION 342
SECTION 2 TRANSPOSITION 348
SECTION 3 GENE EDITING 358
CHAPTER 15 ONCOGENES AND TUMOR SUPPRESSOR GENES 362
SECTION 1 ONCOGENES 362
SECTION 2 TUMOR SUPPRESSOR GENES 372
SECTION 3 COLLABORATIONS OF ONCOGENES AND TUMOR-SUPPRESSOR GENES IN TUMORIGENESIS 381
CHAPTER 16 MOLECULAR CLONING METHODS 384
SECTION 1 GENE CLONING 384
SECTION 2 THE POLYMERASE CHAIN REACTION 396
SECTION 3 EXPRESSING CLONED GENES 398
CHAPTER 17 METHODS FOR STUDYING GENE FUNCTION 403
SECTION 1 MOLECULAR SEPARATIONS 403
SECTION 2 MOLECULAR TOOLS FOR IDENTIFYING GENES 408
SECTION 3 ASSAYING GENE AND GENE PRODUCT INTERACTIONS 422
SECTION 4 ANALYZING GENE FUNCTION IN THE ORGANISM 429
CHAPTER 18 IDENTIFICATION OF DISEASE-RELATED GENES 434
SECTION 1 A ROUTE MAP FOR IDENTIFYING DISEASE GENES 434
SECTION 2 CHROMOSOMAL POSITIONAL CLONING OF DISEASE GENES 434
SECTION 3 CLONING DISEASE GENES INDEPENDENTLY OF THEIR CHROMOSOMAL POSITION 443
SECTION 4 MODELS FOR CLONING DISEASE-RELATED GENES 446
SECTION 5 FUNCTIONAL VALIDATION OF DISEASE GENES 446
CHAPTER 19 GENE DIAGNOSIS 448
SECTION 1 THE CONCEPT AND CHARACTERISTICS OF GENE DIAGNOSIS 448
SECTION 2 THE BASIC TECHNIQUES IN GENE DIAGNOSIS 449
SECTION 3 THE MEDICAL APPLICATION OF GENE DIAGNOSIS 454
CHAPTER 20 GENE THERAPY 459
SECTION 1 STRATEGIES OF GENE THERAPY 459
SECTION 2 PROCEDURES FOR GENE THERAPY 460
SECTION 3 CLINICAL PRACTICE OF GENE THERAPY 477
CHAPTER 21 GENOMICS AND POST-GENOMICS 484
SECTION 1 TECHNIQUES IN GENOMIC SEQUENCING 484
SECTION 2 STUDYING AND COMPARING GENOMIC SEQUENCES 491
SECTION 3 TRANSCRIPTOMICS 497
SECTION 4 PROTEOMICS 503
SECTION 5 OTHER MOLECULAR OMICS STUDY 511
SECTION 6 BIOINFORMATICS 512
INDEX 517
内容摘要
分子生物学是生命科学发展中很重要的前沿领域，也是许多相关学科的理论和技术基础，其在医学研究和医学教育中的重要性更是无论怎样强调也不过分。本书(Textbook of Medical Molecular Biology)作为科学出版社与McGraw-Hill Co.的全套医学教科书合作项目之一，目标是满足医学教育中分子生物学这一核心课程的教学需求。本书读者定位于高等医药院校的来华留学生、特色英文或双语班学生、攻读临床医学专业博士学位学生、研究生和医学院校的青年教师等。
精彩内容
本套英文改编版教材是我社组织国内一流的院士、学者，以国际著名出版公司美国McGraw-HillCo.优秀医学教材为基础，以我国教育部颁布的教学大纲为依据为来华留学生量身制作的全英文医学授课教材。本套教材改编时充分考虑了学科发展及国内外医学教育的现状，结合国内医学教育和来华留学生来源国的教学需求。教材在注重课程体系完整性的同时，延续了学科内容的系统性和连贯性。本书由科学出版社和美国McGraw-HillCo.合作出版。未经出版者预先书面许可，不得以任何方式复制或抄袭本书的任何内容；否则我们将视为违反著作权法，将给予法律追究。
媒体评论
国内第一套改编自经典英文原版的医学教材，语言纯正，并保留原书图文并茂的特色，低价满足国内医药教育需求
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