磁场与生命科学的跨学科研究(英文版) 科学出版社
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作者张欣，王俊峰 著 科技专业 绘
出版社科学出版社
ISBN9787030599100
出版时间2018-11
装帧平装
开本16开
页数456页
定价249元
货号1201827226
上书时间2023-11-08
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内容简介
本书共分16章，介绍了磁场和生命科学在中国的跨学科研究。本书作者来自中国科学院，中国科技大学，厦门大学，浙江大学，东南大学，西北工业大学，南京大学等多个科研机构。本书涵盖了关于磁场与生命科学交叉学科研究的各种主题，包括磁性纳米粒子及其潜在的医疗应用，静态和低频磁场的生物效应及其潜在的临床应用，技术和应用的核磁共振（NMR）和磁共振成像（MRI）在生命科学研究。重点介绍了中国学者近年来的研究进展，同时也包括了国外学者的一些研究进展。
目录
Foreword
Preface
Section 1 Magnetic Fields and Their Biological Effects
Chapter 1 Medical Theranostics Based on Iron Oxide Nanoparticles under Magnetic Fields
1.1 Introduction
1.2 Properties of IONPs under magnetic fields
1.3 Pharmacokinetic and biocompability
1.4 Contrast agents of MRI
1.5 Hyperthermal agents
1.6 Drug delivery systems
1.7 Multimodality theranostics systems of magnetic microbubbles， microcapsules and liposomes
1.8 Other therapeutic potentials
1.9 Summary and future prospective
References
Chapter 2 Progress of Static Magnetic Fields and Cancer Research in China
2.1 Initial clinical studies showed that SMFs could inhibit cancer growth in some patients
2.2 Cellular studies show that SMF inhibits multiple cancer cell growth but has minimum effects on non-cancer cells
2.3 Mechanisms of cancer inhibition by SMFs studied at molecular， cellular and animal levels
2.4 SMF in combination with chemodrugs
2.5 Parameters that directly affect the outcomes of SMF exposure
References
Chapter 3 Study of SMF's Effects on Cells， Microorganisms， Animals and Plants in NPU
3.1 The effects of SMFs on cells
3.2 The effects of SMFs on microorganism
3.3 The effects of SMF on small animals
3.4 The effects of SMFs on plants
References
Chapter 4 In Vitro Cellular Response to ELF-MF and RF-EMF..
4.1 Gap junctional intercellular communication
4.2 Epidermal growth factor receptor (EGFR) clustering
4.3 Stress kinases signaling in response to ELF-MF
4.4 Effect of ELF-MF and RF-EMF on gene expression
4.5 Effect of ELF-MF and RF-EMF on protein expression
4.6 DNA damage response to EMF exposure
References
Chapter 5 Utilization of Magnetic Field for Protein Crystallization
5.1 Introduction
5.2 Effects of magnetic field on protein crystallization
5.3 Quality of protein crystals obtained in the magnetic field
5.4 Toward applications in practical protein crystallization
5.5 Concluding remarks and future perspectives
References
Chapter 6 High Static Magnetic Fields (SMFs) on Reproduction and Development of an Intact Living Organism: Caenorhabditiselegans
6.1 Caenorhabditis elegans ( C. elegans) and its response to magnetic field
6.2 Source of high SMF and exposure procedures
6.3 SMFs on the lifespan and development process of C. elegans
6.4 SMF on brood size and germline apoptosis in C. elegans
6.5 SMF on mitochondrial damage and oxidative stress in C. elegans
References
Chapter 7 Low Frequency Magnetic Field Regulates Immunity and Inhibits Cancer
7.1 Low frequency magnetic field (LF-MF) exposure system
7.2 Screening for suitable tumor parameters of LF-MF
7.3 Tumor inhibition effect of LF-MF
7.4 LF-MF modulated the function of immune system
7.5 LF-MF inhibited adipogenesis of human mesenchymal stem cells
7.6 Research progress of MF in China
7.7 Summary
References
Chapter 8 Moderate Intensity Rotating Low Frequency Magnetic Fields and Their Effects on Human Bodies
8.1 MIR-LF-MF with different parameters
8.2 MIR-LF-MF effects on healthy volunteers
8.3 MIR-LF-MF and high-altitude polycythemia (HAPC)
8.4 MIR-LF-MF effects on patients with chronic diseases
8.5 MIR-LF-MF effects on cancer patients
8.6 General effects of MIR-LF-MR on human bodies and working hypothesis
8.7 Conclusions and perspectives
References
Chapter 9 Advances in Static Magnetic Field Safety Studies
9.1 Laboratory studies with cells
9.2 Laboratory studies with animals
9.3 SMF studies with humans
9.4 Epidemiological studies
References
Section 2 Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI)
Chapter 10 Structural Basis of Biomolecular Interactions Studied by NMR Spectroscopy
10.1 Experimental considerations of NMR-based structural studies
10.2 Proteins related to regulation of gene expression
10.3 Proteins in cell junction
10.4 NMR methodology development for macromolecular structure and dynamics
10.5 NMR application in fragment-based lead discovery
10.6 Summary and outlook
References
Chapter 11 Protein NMR Spectroscopy in Cell-like Environment
11.1 The effect of macromolecular crowding on protein structure and function
11.2 The effect of confinement on protein structure and function
11.3 Protein enrichment in living cells
11.4 Isotopic labeling for protein NMR in cells
11.5 Protein structure and conformation in living cells
11.6 Protein dynamics and interactions in living cells
11.7 Perspective
References
Chapter 12 High-resolution Nuclear Magnetic Resonance Techniques under Inhomogeneous Magnetic Fields
12.1 Introduction
12.2 IMQC-based high-resolution NMR
12.3 SQC-based high-resolution NMR
References
Chapter 13 19F Nuclear Magnetic Resonance/Magnetic Resonance Imaging in China
13.1 Introduction
13.2 Single-modality probes
13.3 Dual-modality probes
13.4 Multi-modality probes
13.5 Others
13.6 Conclusions and future prospects
References
Chapter 14 Ultrasensitive Xenon MRI and Molecular Imaging
14.1 Ultrasensitive pulmonary gas magnetic resonance imaging
14.2 Ultrasensitive HP 129Xe NMR probes
14.3 Microenvironment responsive probes
14.4 Ultralow field magnetic resonance spectroscopy
References
Chapter 15 NMR Applications in Measuring Protein Noncovalent Interactions
15.1 h-bond interaction
15.2 C-H/π interaction
15.3 Electrostatic interaction
15.4 Electric field
References
Chapter 16 Application of Nanodiscs in Examining Protein-Membrane Interaction
16.1 Introduction to nanodiscs
16.2 Self-assembly of nanodiscs
16.3 Properities of nanodiscs
16.4 Application of nanodiscs for studies of membrane proteins
References
Index
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