细胞力学进展李少凡孙博华编高等教育出版社9787040317305

图书标准信息

• 作者 李少凡、孙博华 编
• 出版社 高等教育出版社
• 出版时间 2011-05
• 版次 1
• ISBN 9787040317305
• 定价 89.00元
• 装帧 精装
• 开本 16开
• 纸张 胶版纸
• 页数 284页
• 字数 420千字
• 正文语种 英语

【内容简介】

Inthisbook，wehaveselectednineresearchworksattheforefrontofmolecularandcellularbiomechanicstobeintroducedtoourreaders．It1Souropinionthattheseworksrepresentthecurrenttrendandfuturedirectionsofcellularbiomechanicsresearch．Bycompilingthesedifferenttopicsintoonevolume．auniqueperspectiveiSprovidedonthecurrentstateofcellmechanicsresearchandwhatliesinthefuture．

【目录】

Chapter1ModelingandSimulationsoftheDynamicsofGrowingCellClusters
1.1Introduction
1.2Singlecellgeometryandkinematics
1.2.1Thecontinuummodel
1.2.2Thenumericalmodelforthecellgeometry
1.3Singlecellequilibriumandmaterialmodel
1.3.1Cellequilibrium
1.3.2Thematerialmodel
1.3.3Determinationofmaterialconstants
1.4Modelingcellinteractions
1.4.1Cell-to-cellcontact
1.4.2Cell-to-celladhesion
1.4.3Cell-to-cellinteractiontest
1.5Modelingthecelllifecycle
1.6Detailsofthenumericalimplementation
1.6.1Thefiniteelementmodel
1.6.2Contact/adhesioninterfacedetection
1.6.3Timeintegration
1.6.4Parallelization
1.7Numericalresults
1.8Summaryandconclusions
References

Chapter2MultiscaleBiomechanicalModelingofStemCell-ExtracellularMatrixInteractions
2.1Introduction
2.2CellandECMmodeling
2.2.1Basichypothesisandassumptions
2.2.2Hyperelasticmodel
2.2.3Liquidcrystalmodel
2.3Contactandadhesionmodelsforcell-substrateinteractions
2.3.1Theadhesivebodyforcewithcontinuummechanicscontact
2.3.2Thecohesivecontactmodel
2.4MeshfreeGalerkinformulationandthecomputationalalgorithm
2.5Numericalsimulations
2.5.1Validationofthematerialrhodels
2.5.2Cellresponseinfourdifferentstiffnesssubstrates
2.5.3Cellresponsetoastiffness-varyingsubstrate
2.5.4Comparisonoftwodifferentcontactalgorithms
2.5.5Three-dimensionalsimulationofcellspreading
2.6Discussionandconclusions
References

Chapter3ModelingofProteinsandTheirInteractionswithSolvent
3.1Introduction
3.2Classicalmoleculardynamics
3.2.1Coarse-grainedmodel
3.2.2Highperformancecomputing
3.3Principalcomponentanalysis
3.3.1ThreeoscillatorssystemanalysiswithPCA
3.3.2Quasi-harmonicanalysis
3.3.3Equilibriumconformationalanalysis
3.4Methodsandprocedures
3.4.1Framework
3.4.2Overlapcoefficients
3.4.3Correlationanalysis
3.4.4PCAwithMDsimulation
3.4.5Kabschalgorithm
3.4.6Positionalcorrelationmatrix
3.4.7Clusteranalysis
3.5MDsimulationwithT4lysozyme
3.5.1Equilibrationmeasures
3.5.2Fluctuationanalysis
3.5.3Modeselectionandevaluation
3.5.4Eigenvalueanalysis
3.5.5Overlapevaluation
3.5.6Identificationofslowconformationalflexibility
3.5.7CorrelationanalysisofT4lysozyme
3.6Hemoglobinandsicklecellanemia
……
Chapter4Structural，MechanicalandFunctionalPropertiesofIntermediateChapter5CytoskeletalMechanicsandRheology
Chapter6OntheApplicationofMultiphasicTheoriestotheProblemofChapter7EffectofSubstrateRigidityontheGrowthofNascentAdhesionChapter8Opto-HydrodynamicTrappingforMultiaxialSingle-CellBiomechanics
Chapter9ApplicationofNonlocalShellModelstoMicrotubuleBucklinginLivingCells
AppendixA
AppendixB
AppendixC
AppendixD
References