生物信息学中的数学方法（英文版）

图书标准信息

• 作者 王嘉松、严明 编
• 出版社 科学出版社
• 出版时间 2013-03
• 版次 1
• ISBN 9787030369857
• 定价 88.00元
• 装帧 平装
• 开本 16开
• 纸张 胶版纸
• 页数 199页
• 字数 280千字
• 正文语种 英语

【内容简介】

　　NumericalMethodsinBioinformaticsAnIntroductionpresentsthenumericalmethodsforBioinformaticsasfollowing：severalnumericalsubstitutionsrepresenttheDNAandproteinsequencesasthenumericalorgraphicalsequences;Fourierandwavelettransformsareusedingeneidentificationandproteincomparison;basedonthedatasetofmicroarrayorlipidomicswithhugeamountexperimentdata，suitablestatisticalandalgebraicmethodsareusedinstudyingbiologicalfeaturesoftwosets，undertherepresentationsoffeaturevectors，theclassificationsoftwobiologicalmoleculesarecompletedbyclusteringanalysis;themodelsofdifferentialanddifferenceequationshavebeenconstructedwhichrepresentthebiologicaldynamicprocess;andthetechniquesofmissingdatainputtinghavehelpedtoestimatethemissingentriescomingfrombiologicalobservationsandexperiments，andsoon.Inaddition，somebiologicalconceptsinvolvedbythesemethodsareintroducedalso.

【目录】

PREFACE
CHAPTER1SOMEBIOLOGICALCONCEPTS
1.1Cell
1.2GeneticMaterial：DNA,GeneandRNA
1.2.1DNA
1.2.2Gene
1.2.3RNA
1.3ProteinandAminoAcids
1.4Chromosome
1.5Omics
1.5.1Genomics
1.5.2Microarray
1.5.3Proteomics
1.5.4Lipidomics
REFERENCES

CHAPTER2GRAPHICALREPRESENTATIONSOFDNASEQUENCE
2.1Three-Dimension（3-D）GraphicaIRepresentation
2.22-DGraphicalRepresentatio
2.32-DGraphicalRepresentationsWithoutDegeneracy
2.4Useda1-DNumerioalRepresentationoffourNucleotidestoConstructa2-DGraplucalRepresentationoftheDNASequence
REFERENCES

CHAPTER3NUMERICALREPRESENTATIONSOFDNASEQUENCE
3.14-Dand3-DNumericalRepresentationsofaDNASequence
3.22-DNumericalRepresentationsofaDNASequence
3.3TheComplexNumericalRepresentation
3.41-DNumericalRepresentationsoffourNucleotidesand2-DGraphical
RepresentationofaDNASequence
3.5TheRepresentationsofFeatureVector,GenomeSpaceandMatrixRepresentationofDNASequence
3.6TheNumericalRepresentationBasedonPhysical,ChemicalandStructural
PropertiesofDNASequence
3.6.1Thenumericalrepresentationsbasedonsomeattributeequivalences
ofnucleotides
3.6.2TherepresentationofDNAbytheinspirationfromcodonandtheideaofthreeattributeequivalences
3.6.3EIIPnumericalrepresentationfornucleotides
REFERENCES

CHAPTER4NUMERICALREPRESENTATIONSOFPROTEIN
4.11-DNumericalandGraphicalRepresentationsoftheAminoAcidSequence
4.22-DNumericalandGraphicalRepresentationsoftheAminoAcidSequence
4.3A2-DGraphicalRepresentationandMomentVectorRepresentationofProtein
4.43-DNumericalRepresentationofProtein
4.5The10-DRepresentationofanAminoAcid
4.6TheVectorandMatrixRepresentationsofProteinSequenceandProteinSpace
4.7OtherSchemesoftheRepresentationforProtein
REFERENCES

CHAPTER5PRACTICALORTHOGONALTRANSFORM
5.1SomeFeaturesandAlgorithmsfortheDiscreteFourierTransform
5.1.1Fouriertransformsoftheoriginalsequenceanditssubsequence
5.1.2TheindependencyoftheFouriertransformsatseveralfrequencies
5.1.3TheFouriertransformofsymbolicsequence
5.1.4Fouriertransformofbinarysequence
5.1.5SeveralalgorithmsofFouriertransform
5.1.6ThepropertiesofFouriertransformofrealsequence
5.2WaveletAnalysis
5.2.1Introduction
5.2.2MultiresolutionanalysisofafunctionbyHaarscalingandwavelet
function
5.2.3Constructionofwaveletsystems
5.2.4Mallettransform
REFERENCES
……

CHAPTER6IDENTIFYINGPROTEIN-CODINGREGIONS（EXONS）BYNUCLEOTIDEDISTRIBUTIONS

CHAPTER7PROTEINCOMPARISONBYORTHOGONALTRANSFORMS
CHAPTER8THEAPPLICATIONOFVECTORREPRESENTATIONSTOBIOLOGICALMOLECULEANALYSIS
CHAPTER9THESTATISTICSANALYSISOFLARGEAMOUNTOFEXPERIMENTALDATA
CHAPTER10APPLYSINGULARVALUEDECOMPOSITIONTOMICROARRAYANALYSIS
CHAPTER11DYNAMICALANALYSISMODELSOFGENEEXPRESSION
CHAPTER12MISSINGMICROARRAYDATAINPUTTING

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