Clinical Trials: A Methodologic Perspective Second Edition

图书标准信息

• 作者 Steven Piantadosi 著
• 出版社 Wiley-Interscience
• 出版时间 2005-08
• 版次 2
• ISBN 9780471727811
• 定价 1345.50元
• 装帧 精装
• 开本 其他
• 纸张 其他
• 页数 720页
• 正文语种 英语
• 丛书 Wiley Series in Proability and Statistics

【内容简介】

Learnrigorousstatisticalmethodstoensurevalidclinicaltrials

ThisSecondEditionofthecriticallyhailedClinicalTrialsbuildsonthetext'sreputationasastraightforwardandauthoritativepresentationofstatisticalmethodsforclinicaltrials.Readersareintroducedtothefundamentalsofdesignforvarioustypesofclinicaltrialsandthenskillfullyguidedthroughthecompleteprocessofplanningtheexperiment,assemblingastudycohort,assessingdata,andreportingresults.Throughouttheprocess,theauthoralertsreaderstoproblemsthatmayariseduringthecourseofthetrialandprovidescommonsensesolutions.

Theauthorbasestherevisionsandupdatesonhisownclassroomexperience,aswellasfeedbackfromstudents,instructors,andmedicalandstatisticalprofessionalsinvolvedinclinicaltrials.TheSecondEditiongreatlyexpandsitscoverage,rangingfromstatisticalprinciplestocontroversialtopics,includingalternativemedicineandethics.Atthesametime,itoffersmorepragmaticadviceforissuessuchasselectingoutcomes,samplesize,analysis,reporting,andhandlingallegationsofmisconduct.ReadersfamiliarwiththeFirstEditionwilldiscovercompletelynewchapters,including:
*Contextsforclinicaltrials
*Statisticalperspectives
*Translationalclinicaltrials
*Dose-findinganddose-rangingdesigns

Eachchapterisaccompaniedbyasummarytoreinforcethekeypoints.Reviseddiscussionquestionsstimulatecriticalthinkingandhelpreadersunderstandhowtheycanapplytheirnewfoundknowledge,andupdatedreferencesareprovidedtodirectreaderstothemostrecentliterature.

Thistextdistinguishesitselfwithitsaccessibleandbroadcoverageofstatisticaldesignmethods--thecrucialbuildingblocksofclinicaltrialsandmedicalresearch.Readerslearntoconductclinicaltrialsthatproducevalidqualitativeresultsbackedbyrigorousstatisticalmethods.

【作者简介】

STEVENPIANTADOSI,MD,Phd,isProfessorofOncologyandDirectorofBiostatisticsattheJohnsHopkinsOncologyCenter.HealsoholdsappointmentsintheDepartmentsofBiostatisticsandEpidemiologyattheBloombergSchoolofPublicHealthatJohnHopkinsUniversity.Dr.Piantadosihastaughtclinicaltrialsforseventeenyearsandistheauthororcoauthorofmorethan250scholarlyarticles.