内容提要 生物信息计算是在生命科学的研究中,以计算机为工具对生物信息进行储存、检索和分析的科学,是当今生命科学和自然科学的重大前沿领域之一。本书重点集中在基因组学和蛋白质组学两方面,分12章介绍:序列数据资源及其检索、蛋白质序列数据库、序列比对与比对搜索、真核生物基因结构的预测分析、分子进化分析、蛋白质结构数据库和结构可视化、蛋白质结构与功能预测、微阵列数据分析、系统生物学网络结构分析等内容,并对Gene Ontology数据库、KEGG数据库及基因功能注释、R编程及Bioconductor进行了简要简述和应用示例。 本书是计算机科学、生物信息学以及统计学的知识综合,可供相关领域的专业人员参考使用,也可用于生物学、计算机科学专业的教学。 目录 PART Ⅰ DATABASES AND BIOINFORMATICS TOOLSChapter 1 Online Sequence Database1.1 Nucleic Acid Sequence Database1.2 Protein Database1.3 Protein Three-Dimensional Structure Database PDB1.4 Genome BrowserReferencesChapter 2 Sequence Alignment2.1 Pairwise Sequence Alignment2.2 Multiple Sequence Alignment2.3 Basic Local Alignment Search ToolReferencesChapter 3 Molecular Phylogeny and Evolution3.1 Introduction to Molecular Evolution3.2 Models of DNA and Amino Acid Substitution3.3 Tree-Building Method3.4 Evaluating Tree3.5 PerspectivesReferencesChapter 4 Predicting DNA and Protein Function from Sequence4.1 DNA Sequence Analysis4.2 Protein Sequence AnalysisReferencesChapter 5 Protein Structure5.1 Overview of Protein Structure5.2 Principles of Protein Structure5.3 Protein Structure Prediction5.4 Protein Structure Determining and AnalysisReferencesPART Ⅱ BIOINFORMATICS FOR OMICS DATAChapter 6 Human Genetic Variation and Human Disease6.1 Human Genetic Variation6.2 Human DiseaseReferencesChapter 7 Gene Expression Profiling with Microarray: Online Resources and Data Management7.1 Microarray Data Analysis Software7.2 Microarray Databases7.3 Microarray Data AnalysisReferencesChapter 8 Bioinformatics for Qualitative and Quantitative Proteomics8.1 Protein Identification and Quantification from MS Raw Data8.2 Proteomics Data Analysis8.3 Proteomics Data Storage, Exchange and SharingReferencesChapter 9 Bioinformatics for Metabolomics9.1 Metabonomics and Metabolomics9.2 Basic Approaches to Study Metabonomics9.3 Data Analysis Methods9.4 Metabonomics Databases9.5 Summary 作者介绍
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