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现货Tetrahydrobiopterin and nitric oxide synthase regulation[9783639164008]
￥ 700 九五品
仅1件
上海宝山
认证卖家担保交易快速发货售后保障
作者Alp, Nicholas
出版社VDM Verlag
ISBN9783639164008
出版时间2009-06
装帧平装
纸张其他
页数140页
正文语种英语
上书时间2023-08-15
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- Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key mediator of vascular homeostasis. eNOS enzymatic activity appears to be determined by the availability of its cofactor tetrahydrobiopterin (BH4). BH4 bioavailability is limited by oxidative degradation in dysfunctional endothelium, and by alterations in the rate of its biosynthesis, governed by the rate-limiting enzyme GTP cyclohydrolase 1 (GTPCH). In this project novel targeted transgenic mouse lines were generat
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