Pain remains one of the most common conditions studied by sensory and clinical neuroscience today, with approximately 3 to 4.5 perecnt of the global population suffering from chronic neuropathic pain. Pain conditions discussed in this volume are somatic, chronic, and unresponsive, associated with other forms of abnormal sensations, and can be thus described as pathological, neurological disorders. Shifting attention from the area of initial pathology to the supposedly "intact" brain represents a novel approach, and mounting evidence indicates that the brain undergoes changes at molecular, cellular and circuitry levels when pain is untreated for several months. Further research in this area should lead to an understanding of the mechanisms which lead to development of a pain "biomarker" for diagnostic purposes, as well as new therapies that target the brain via surgical or technological approaches. Chronic Pain and Brain Abnormalities includes evidence for pain-related changes in the brain in human patients and in animal models. Data at the molecular, cellular and circuitry levels is integrated, and it is the novel synthesis of these data that is emphasized. Tools for investigation in the clinical laboratory setting will be discussed, using both invasive and non-invasive techniques, and the authors will propose theories and strategies for treatment as well as discuss the limitations of pain treatment at this point. Authored by the international leading experts in the field, the book provides the only accurate, up-to-date coverage on chronic pain and brain abnormalities on the market today.
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