Fluorine (19F) magnetic resonance imaging (MRI) has garnered significant interest owing to the properties of fluorinated materials and the 19F nucleus. Fluorinated materials can serve as therapeutic agents, drug-delivery vehicles, and imaging probes that rely on 19F MRI detection. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body, thus, no background signal. Fluorine-containing compounds are ideal tracer labels for many MRI applications. Moreover, the chemical shift and nuclear relaxation rate is responsive to physiology via creative molecular design.
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