Impaired sleep and alertness is a major non-motor manifestation of Parkinsons disease (PD). Sleep dysfunction, which affects up to 90% of patients with Parkinsons disease, remains under-reported by patients and under-diagnosed by physicians and health professionals. Recently, sleep dysfunction has increasingly been recognized as a risk factor for development of Parkinsons disease. Disorders of Sleep and Wake in Parkinsons Disease is the first book to take into account the rapidly accumulating knowledge related the interface of sleep and PD.With contributionsfrom internationally recognized experts, the book is a single source of in-depth information on sleep and circadian dysregulation in Parkinsons disease. It is divided into two parts: the first comprises chapters summarizing normal sleep-wake homeostasis, followed by changes that occur in PD and discussions of available tools for the assessment of sleep-wake cycles in PD. In the second part, sleep and circadian disorders associated with PD are being described in individual chapters, including sections on epidemiology, etiology, pathogenesis, differential diagnosis, and treatment. Controversies in the field, such as the interface of cognition and sleep, fatigue and sleepiness, as well as the potential impact of surgical therapies on sleep-wake cycles will be discussed separately. The book concludes with a chapter on future directions and unmet needs in the field of sleep, circadian biology and PD. This comprehensive text is readily accessible to both clinicians and researchers and addresses neurologists, sleep and movement disorders specialists, and all trainees as well as allied health professionals involved in the care of patients affected by Parkinsons Disease.
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