现货 Drug Bioavailability (Revised) (Methods & Principles in Medicinal Chemistry)[9783527320516]

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作者Waterbeemd, Han Van de ; Testa, Bernard ; Mannhold, Raimund ; Kubinyi, Hugo ; Folkers, Gerd

出版社Wiley-Vch

ISBN9783527320516

出版时间2008-11

装帧精装

纸张其他

页数649页

正文语种英语

上书时间2023-04-10

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商品描述: In 21 chapters by drug developers from industry and academia, the current knowledge on all factors governing drug bioavailability is presented, complete with practical examples and real-life data. Part I focuses on in vitro and in vivo measurements of physicochemical properties such as membrane permeability and ionisation. Part II discusses solubility and gastrointestinal absorption, part III is devoted to metabolism and exretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how a poor bioavailability may be improved by various approaches during drug development.

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