A peculiar feature of the mammalian hippocampus is that it maintains the ability to generate new neurons throughout adult life while most other areas of the brain do not. In this book, we outline evidence for the functional consequences of adult neurogen nesis in the dentate gyrus highlighting a possible role in learning and memory and depression. Presynaptic modulation at the MF synapse is also described with respect to its involvement in the activity-dependent nature of the MF synapse and contribution
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