药用高分子
正版保障 假一赔十 可开发票
￥ 47.69 5.4折 ￥ 88 全新
库存8件
作者王者辉 主编
出版社化学工业出版社
ISBN9787122324832
出版时间2018-10
装帧平装
开本16开
定价88元
货号25338936
上书时间2024-10-25
商品详情
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前言
前言药用高分子（Pharmaceutical polymers）是具有生物相容性、经过安全评价且应用于药物制剂的一类高分子量药用辅料。药用高分子作为药物缓释载体，包覆在药物表面保护小分子药物使其在短时间内不会被生命体吸收，同时随血液流动到特定区域，在特定区域药物表面的高分子材料溶解到血液中，释放出药物，而本身终随体液排出。药用高分子的主要应用有：①载体，用以控制药物缓慢释放，一般由有机硅橡胶、聚甲基丙烯酸酯类等制成封闭细管、微囊或薄膜。②主药，有长效的特点，其结构有三类：（a）在高分子侧基上连接小分子药物，这类结构受重视，即高分子亲和药物，在高分子侧链上除含有药物结构外，在较远端侧链上还含有亲水结构、配基或酶，以提高药用高分子在体内分布的专一性；（b）在高分子主链中含小分子药物；（c）高分子中不含小分子药物，其本身可作为药物或功能试剂。本书结合现代药剂学的发展以及作者多年来的教学科研实践，根据国内外资料，简述了有关高分子化学和物理的基本内容，概述了与药剂学相关的高分子材料基本知识，重点介绍国际上经法定程序验证及实际生产中已被采用的药用高分子材料的原理和应用，充实了国外近年来备受瞩目的给药系统用天然来源药用高分子及可生物降解的合成药用高分子和复合物的有关内容，此外，还对热分析、原子力显微镜和流变学在药用高分子领域中的应用进行了阐述。本书可供普通高等医药院校药学、药物制剂、制药工程、高分子材料与工程等相关专业学生及从事药物制剂生产、研究的人员参考使用。全书共分为十章，参与本书编写的人员及具体编写分工如下：章由孙红、王者辉编写；第二章由张宏志、孙立平编写；第三章由巩学勇、刘凤霞编写；第四章由李庆杰、常海涛编写；第五章由郑超、张倩编写；第六章由刘光耀、江栋编写；第七章由卫振华、刘爱军编写；第八章由王者辉、李宝庆编写；第九章由杜江山、刘振亮编写；第十章由姜洪丽、孟宪锋编写；全书由王者辉统一整理并任主编。由于水平所限，书中不足之处在所难免，诚恳希望广大读者加以批评指正。编 者2018年5月PrefacePharmaceutical polymers (both synthetic and natural-based polymers) have found their way into the pharmaceutical industries and their applications are growing at a fast pace. The desirable polymer properties in pharmaceutical applications are film forming (coating), thickening (rheological modifier), gelling (controlled release), adhesion (binding), pH-dependent solubility (controlled release), solubility in organic solvents (taste masking), and barrier properties (protection and packaging). Major applications of polymers in current pharmaceutical field are for controlled drug release. From the solubility point of view, pharmaceutical polymers can be classified as water-soluble and water-insoluble (oil soluble or organic soluble). Many water-soluble pharmaceutical polymers including polyethylene glycol, polyvinyl alcohol, polyethylene oxide, polyvinyl pyrrolidone, polyacrylate or polymethacrylate esters, cellulose based polymers, hydrocolloids, and many plastics and rubbers will be tabulated and their anionic and cationic functionalities are summarized and discussed. PEGylation is defined as the covalent attachment of poly ethylene glycol (PEG) chains to bioactive substances. Pharmaceutical polymer, a kind of macromolecular compound with bioco- mpatibility, safety evaluation, is used as a kind of high molecular mass pharma- ceutical excipients for drug preparation. As a sustained release drug carrier, the pharmaceutical polymer is coated on the surface of the drug to protect small molecular weight drugs not to be absorbed by the living body in a short time. At the same time, with the flow of blood in a specific area, the polymer materials on the specific area of the drug dissolve into the blood and release the drug, and the drug itself is eventually discharged with the body fluid. The main applications of pharmaceutical polymers include: (1) the carrier, which is used to control the slow release of drugs, usually made of organosilicon rubber, polymethacrylate and others in the form of closed tubes, microcapsules or films. (2) the main drug with characteristic long time efficacy has three kinds of structures: (i) polymeric affinity drug, with the hydrophilic groups, the ligands or enzymes on the far end of the chain, have small molecular drugs connecting on the side of the polymer chains, which is the most important structure with pharmaceutical polymer uniform distribution inside the body; (ii) polymeric drug contains small molecule drugs in the main chain; (iii) polymers do not contain small molecular drugs, it act as medicine or functional reagent. This book, combined with the development of modern pharmaceutics and many years practice of teaching and scientific research, briefly describes the founda- mentals of polymer chemistry and physics, and summarizes the basic knowledge of polymers related to pharmaceutics. According to the latest information at home and abroad, this book mainly introduces the principles and applications of pharma- ceutical polymers that have been used in international legal procedure verification and actual production, and enriches the related contents of natural sources of pharmaceutical polymers and biodegradable synthetic pharmaceutical polymers and complexes in recent years. The applications of thermal analysis, atomic force microscopy and rheology in the field of pharmaceutical polymers are included. This book can be used as a reference for readers of pharmaceutical engineering, polymer materials and engineering and related majors and people engaged in the production and research of pharmaceutical preparations.The personnel involved in this book include: the first chapter by Hong Sun and Zhehui Wang; the second chapter by Hongzhi Zhang and Liping Sun; the third chapter by Xueyong Gong and Fengxia Liu; the fourth chapter by Qingjie Li and Haitao Chang; the fifth chapter by Chao Zheng and Qian Zhang; the sixth chapter by Guangyao Liu and Dong Jiang; the seventh chapter by Zhenhua Wei and Aijun Liu; the eighth chapter by Zhehui Wang and Baoqing Li; the ninth chapter by Jiangshan Du and Zhenliang Liu; the tenth chapter by Hongli Jiang and Xianfeng Meng; this whole book is edited by Zhehui Wang. As to the limitation of the authors’ level, all kinds of criticisms are welcome for various mistakes in the book, and we sincerely hope that readers will be able to inform us for correction.Zhehui Wang2018.5
导语摘要
《Pharmaceutical Polymers（药用高分子）》基于现代药剂学的发展，依据国内外*资料，结合作者多年来的教学科研实践编写而成，系统讲述了高分子在药物制剂中的应用。全书共分为十章，具体内容包括：药用高分子化学基础理论（*章）；药用高分子的原理与结构（第二章）；天然来源与合成药用高分子（第三章）；天然来源高分子在药学领域的应用（第四章）；疏水性高分子聚合物的药用价值（第五章）；高分子聚合物在药物传递中的应用（第六章）；医药纳米技术（第七章）；药用高分子的热分析（第八章）；原子力显微镜在药用高分子中的应用（第九章）；药物高分子的流变学研究（第十章）。《Pharmaceutical Polymers（药用高分子）》可供普通高等医药院校药学、药物制剂、制药工程、高分子材料与工程等相关专业学生及从事药物制剂生产、研究的人员参考使用。
作者简介
王者辉，泰山医学院，副教授， 自2004年以来，长期从事高分子材料专业的本、专科的教学，教授的课程主要有材料导论、专业英语、聚合物改性、涂料化学、光化学与光物理、波谱分析、聚合物加工流变学、高分子材料概论等。科研方向为医用高分子材料、高分子界面。
目录Chapter 1
Fundamentals of Pharmaceutical Polymer Chemistry 1
1.1 The Concept of a Polymer 1
1.2 Addition Polymerization 4
1.3 Chain Branching; Graft and Block
Copolymers 15
1.4 Polymer Structure and Properties 18
1.5 Technology of Polymerization 24
1.6 The Principal Monomers and Their
Polymers 27
1.7 Physical Properties of Monomers 37
References 41
Chapter 2 Pharmaceutical Polymers:
Principles and Structures 42
2.1 Introduction 42
2.2 Intra and Inter Polymer Molecular
Interactions 45
2.3 Molecular Mass: Polydispersivity and
Effects on Polymer Viscosity 47
2.4 Thermal Properties: Effect of
Crystalline and Amorphous Phases 51
2.5 Mechanical Properties of Polymers 54
2.6 Pharmaceutical Polymers: Principles,
Structures, and Applications of Pharmaceutical Delivery Systems 61
References 80
Chapter 3 Polymers as Drugs 81
3.1 Introduction 81
3.2 Polymers for Molecular Sequestration
83
3.3 Polyvalent Interactions and
Anti-Infective Polymeric Drugs 95
3.4 Polymeric Drugs for the Treatment of
Autoimmune Diseases 105
3.5 Polymeric Anti-Obesity Drugs 107
3.6 Polymer Therapy for Sickle Cell
Disease 111
3.7 Conclusions and Outlook on Polymers
as Drugs 112
References 113
Chapter 4 Pharmaceutical Applications of
Natural Polymers 114
4.1 Introduction 114
4.2 Portals of Drug Administration in
the Human Body 116
4.3 Transdermal Drug Delivery Devices
117
4.4 Topical Drug Delivery 124
4.5 Oral Drug Delivery System 131
4.6 Parenteral Drug Delivery Systems 132
4.7 Nasal Drug Delivery Systems 134
4.8 Hydrogel-Based Drug Delivery Systems
136
References 147
Chapter 5 Hydrophobic Polymers of
Pharmaceutical Significance 149
5.1 Introduction 149
5.2 Examples of Hydrophobic Polymers and
Their Drug Delivery Applications 150
5.3 Conclusions 167
References 168
Chapter 6 Polymers in Drug Delivery 169
6.1 Evolution of Drug Dosage Forms 169
6.2 Polymer Excipients 172
6.3 Polymers as Manufacture Aids and
Sustained Release 174
References 200
Chapter 7 Pharmaceutical Nanotechnology:
Overcoming Drug Delivery Challenges in Contemporary Medicine 202
7.1 Challenges in Delivery of
Contemporary Therapeutics 202
7.2 Nanotechnology Solutions 207
7.3 Illustrative Examples of
Nanotechnology Products 211
7.4 Multifunctional Nanotechnology 218
7.5 Regulatory Issues in
Nano-pharmaceuticals 225
7.6 Conclusions and Future Outlook 235
References 235
Chapter 8 Thermal Analysis of
Pharmaceutical Polymers 237
8.1 Introduction 237
8.2 Theoretical Background of Thermal
Analysis 238
8.3 Physical and Chemical Phenomena
Commonly Investigated Using Thermal Approaches 244
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