CONTENTS Chapter l Introduction 1 Chapter 2 Pharmacokinetics and Pharmacodynamics: Rational Dosing and the Time Course of Drug Action 2 Chapter 3 Drug Receptors and Pharmacodynamics 17 Chapter 4 Drug Biotransformation 41 Chapter 5 Development and Regulation of Drugs 48 SECTIONⅡ AUTONOMIC DRUGS Chapter 6 Introduction to Autonomic Pharmacology 59 Chapter 7 Cholinoceptor-Activating Drugs and Cholinesterase-Inhibiting Drugs 67 Chapter 8 Cholinoceptor-Blocking Drugs 74 Chapter 9 Adrenoceptor Agonists and Sympathomimetic Drugs 80 Chapter 10 Adrenoceptor Antagonist Drugs 95 SECTION Ⅲ DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM Chapter 11 Introduction to the Pharmacology of CNS Drugs 104 Chapter 12 Sedative-Hypnotic Drugs 119 Chapter 13 The Alcohols 135 Chapter 14 Antiseizure Drugs 141 Chapter 15 General Anesthetics 148 Chapter 16 Local Anesthetics 155 Chapter 17 Skeletal Muscle Relaxants 164 Chapter 18 Pharmacologic Magnagement of Parkinsonisn and Other Movement Disorders 180 Chapter 19 Antipsychotic Agents and Lithium 187 Chapter 20 Antidepressant Agents 195 Chapter 21 Opioid Analgesics and Antagonists 205 Chapter 22 Drugs of Abuse 218 SECTION Ⅳ CARDIOVASCULAR-RENAL DRUGS Chapter 23 Antihypertensive Agents 223 Chapter 24 Vasodilators and the Treatment of Angina Pectoris 231 Chapter 25 Drugs Used in Heart Failure 248 Chapter 26 Agents Used in Cardiac Arrhythmias 262 Chapter 27 Diuretis 276 SECTIONⅤ DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE Chapter 28 Vasoactive Peptides 294 Chapter 29 The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, and Related Compounds 301 Chapter 30 Nitric Oxide 318 Chapter 31 Drugs Used in Asthma 325 SECTION Ⅵ ENDOCRINE DRUGS Chapter 32 Hypothalamic and Pituitary Hormones 332 Chapter 33 Thyroid and Antithyroid Drugs 347 Chapter 34 Adrenocorticosteroids and Adrenocortical Antagonists 358 Chapter 35 The Gonadal Hormones and Inhibitors 374 Chapter 36 Pancreatic Hormones and Antidiabetic Drugs 400 Chapter 37 Agents That Affect Bone Mineral Homeostasis 407 SECTION Ⅶ AUTOCOIDS AND ANTI-AUTOCOID DRUGS Chapter 38 Histamine, Serotonin, and the Ergot Alkaloids 413 SECTION Ⅷ DRUGS USED TO TREAT DISEASES OF THE BLOOD, IN-FLAMMATION, AND GOUT Chapter 39 Agents Used in Anemias; Hematopoietic Growth Factors 424 Chapter 40 Drugs Used in Disorders of Coagulation 434 Chapter 41 Agents Used in Dyslipidemia 443 Chapter 42 Nonsteroidal Anti-Inflammatory Drugs, Nonopioid Analgesics, Anti-Rheumatic Drugs, and Drugs Used in Gout 448 SECTION Ⅸ DRUGS THAT ACT IN THE IMMUNE SYSTEM Chapter 43 Immunopharmacology 456 SECTION Ⅹ CHEMOTHERAPEUTIC DRUGS Chapter 44 β-Lactam and Other Inhibitors of Cell Wall Synthesis 464 Chapter 45 Tetracyclines, Macrolides, Clindamycin Streptogramins, and Chloramphenicol 477 Chapter 46 Aminoglycosides and Spectinomycin 486 Chapter 47 Sulfonamides, Trimethoprim, and Quinolones 492 Chapter 48 Antimycobacterial Drugs 497 Chapter 49 Antifungal Agents 505 Chapter 50 Antiviral Agents 511 Chapter 51 Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, and Sterilants 516 Chapter 52 Clinical Use of Antimicrobial Agents 522 Chapter 53 Antiprotozoal Drugs 529 Chapter 54 Clinical Pharmacology of the Antihelminthic Drugs 553 Chapter 55 Cancer Chemotherapy 561 SECTION Ⅺ TOXICOLOGY Chapter 56 Introduction to Toxicology: Occupational and Environmental 569 Chapter 57 Heavy Metal Intoxication and Chelators 574 Chapter 58 Management of the Poisoned Patient 585 SECTION Ⅻ SPECIAL TOPICS Chapter 59 Special Aspects of Perinatal and Pediatric Pharmacology 590 Chapter 60 Special Aspects of Geriatric Pharmacology 595 Chapter 61 Dermatologic Pharmacology 598 Chapter 62 Drugs Used in the Treatment of Gastrointestinal Diseases 616 Chapter 63 Therapeutic and Toxic Potential of Over-the-Counter Agents 622 Chapter 64 Dietary Supplements and Herbal Medications 634 Chapter 65 Rational Prescribing and Prescription Writing 644 Chapter 66 Important Drug Interactions and Their Mechanisms 648 English-Chinese Indexes 661
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