1信号转导与转录激活因子3(STAT3)抑制剂及其抗肿瘤研究进展1 Progress in the Research of STAT3 Inhibitors as Anticancer Agents 余文颖李洋孔令义 2选择性EGFR T790M抑制剂的研究进展17 Recent Advance on the Discovery of T790M Mutantselective EGFR Inhibitors 徐石林徐田锋丁克3FLT 3ITD及其抑制剂的研究进展38 Advances in FLT3 Internal Tandem Duplications Mutation and Inhibitors of FLT3ITD 钟杭蔡婷赵临襄 4组蛋白去甲基化酶及其抑制剂的研究进展57 Progress in the Research of Histone Demethylases and Their Inhibitors 郑一超刘宏民 5 组蛋白去乙酰化酶抑制剂研究进展77 Progress in Histone Deacetylase Inhibitors 安娜高明邓卫平 6NAD+依赖的组蛋白去乙酰化酶(Sirtuin)激活剂与抑制剂的研究进展107 Progress in NAD+dependent Sirtuins Activators and Inhibitors 王磊方浩 7靶向IKKβ激酶抑制剂的研究进展120 Progress in Targeting IKKβ Kinase Inhibitors 褚红喜黄婧婕孙昊鹏尤启冬 8缺氧诱导因子(HIF)介导肿瘤耐药及其相关药物的研究进展131 The Research Development of Hypoxiamediated Drug Resistance and Drug Candidates 陈亚琼彭晖 9天然萜类化合物逆转肿瘤和细菌多药耐药的研究进展159 Progress in the Research of Natural Terpenes as Reversal Agents of Multidrug Resistance in Cancer and Bacteria 张恒源徐进宜 10抗菌肽设计的研究进展179 Recent Studies on Designing Antimicrobial Peptides 张伟谢俊秋张邦治王锐 11治疗糖尿病的新策略——SGLT2抑制剂202 A Novel Strategy for Diabetes TreatmentSGLT2 Inhibitors 王学堃钱海黄文龙 12GPR40 和GPR120调控剂的研究进展225 Progress in GPR40 and GPR120 Modulators 雷显涛温小安孙宏斌 13抗阿尔茨海默病药物研究进展255 Progresses of the Development of antiAlzheimer Drugs 房雷苟少华 14载体转运系统介导的脑靶向药物研究进展281 Progress in Carriermediated Brain Targeting Drugs 吴勇李晓岑海俐 15与重大疾病相关的糖类药物的研究进展303 Progress in the Research of Carbohydratebased Drugs Associated with Major Diseases 王晓丽田光宗汪学彬尹健 16一氧化氮供体偶氮二醇盐的O2保护策略及其应用研究进展321 Research Progress in O2protection and Application of Nitric Oxide Donor Diazeniumdiolates 黄张建赖宜生彭司勋张奕华
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